A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study.
Identifieur interne : 001A21 ( Main/Exploration ); précédent : 001A20; suivant : 001A22A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study.
Auteurs : R. Daglas [Australie] ; S M Cotton [Australie] ; K. Allott [Australie] ; M. Yücel [Australie] ; C A Macneil [Australie] ; M K Hasty [Australie] ; B. Murphy [Australie] ; C. Pantelis [Australie] ; K T Hallam [Australie] ; L P Henry [Australie] ; P. Conus [Suisse] ; A. Ratheesh [Australie] ; L. Kader [Australie] ; M Th Wong [Australie] ; P D Mcgorry [Australie] ; M. Berk [Australie]Source :
- European psychiatry : the journal of the Association of European Psychiatrists [ 1778-3585 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Antimaniacodépressifs (usage thérapeutique), Apprentissage verbal (MeSH), Cognition (effets des médicaments et des substances chimiques), Composés du lithium (usage thérapeutique), Dibenzothiazépines (usage thérapeutique), Facteurs temps (MeSH), Femelle (MeSH), Fumarate de quétiapine (usage thérapeutique), Humains (MeSH), Intelligence (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Mémoire (MeSH), Méthode en simple aveugle (MeSH), Neuroleptiques (usage thérapeutique), Résultat thérapeutique (MeSH), Trouble bipolaire (psychologie), Trouble bipolaire (traitement médicamenteux), Études de suivi (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Cognition.
- psychologie : Trouble bipolaire.
- traitement médicamenteux : Trouble bipolaire.
- usage thérapeutique : Antimaniacodépressifs, Composés du lithium, Dibenzothiazépines, Fumarate de quétiapine, Neuroleptiques.
- Adolescent, Adulte, Apprentissage verbal, Facteurs temps, Femelle, Humains, Intelligence, Jeune adulte, Mâle, Mémoire, Méthode en simple aveugle, Résultat thérapeutique, Études de suivi.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Antimanic Agents (therapeutic use), Antipsychotic Agents (therapeutic use), Bipolar Disorder (drug therapy), Bipolar Disorder (psychology), Cognition (drug effects), Dibenzothiazepines (therapeutic use), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Intelligence (MeSH), Lithium Compounds (therapeutic use), Male (MeSH), Memory (MeSH), Quetiapine Fumarate (therapeutic use), Single-Blind Method (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH), Verbal Learning (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antimanic Agents, Antipsychotic Agents, Dibenzothiazepines, Lithium Compounds, Quetiapine Fumarate.
- drug effects : Cognition.
- drug therapy : Bipolar Disorder.
- psychology : Bipolar Disorder.
- Adolescent, Adult, Female, Follow-Up Studies, Humans, Intelligence, Male, Memory, Single-Blind Method, Time Factors, Treatment Outcome, Verbal Learning, Young Adult.
Abstract
BACKGROUND
Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania.
METHODS
The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and month 12 follow-up time-points.
RESULTS
There was a significant interaction between group and time in phonemic fluency at the 3-month and 12-month endpoints, reflecting greater improvements in performance in lithium-treated participants relative to quetiapine-treated participants. After controlling for multiple comparisons, there were no other significant interactions between group and time for other measures of cognition.
CONCLUSION
Although the effects of lithium and quetiapine treatment were similar for most cognitive domains, the findings imply that early initiation of lithium treatment may benefit the trajectory of cognition, specifically verbal fluency in young people with bipolar disorder. Given that cognition is a major symptomatic domain of bipolar disorder and has substantive effects on general functioning, the ability to influence the trajectory of cognitive change is of considerable clinical importance.
DOI: 10.1016/j.eurpsy.2015.09.460
PubMed: 26655594
Affiliations:
- Australie, Suisse
- Canton de Vaud, Victoria (État)
- Lausanne, Melbourne
- Université de Lausanne, Université de Melbourne
Links toward previous steps (curation, corpus...)
Le document en format XML
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Yücel</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Brain and Mental Health Laboratory (BMH), School of Psychological Sciences & Monash Biomedical Imaging Facility, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Brain and Mental Health Laboratory (BMH), School of Psychological Sciences & Monash Biomedical Imaging Facility, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Macneil, C A" sort="Macneil, C A" uniqKey="Macneil C" first="C A" last="Macneil">C A Macneil</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Hasty, M K" sort="Hasty, M K" uniqKey="Hasty M" first="M K" last="Hasty">M K Hasty</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Murphy, B" sort="Murphy, B" uniqKey="Murphy B" first="B" last="Murphy">B. Murphy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychiatry, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C" last="Pantelis">C. Pantelis</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Hallam, K T" sort="Hallam, K T" uniqKey="Hallam K" first="K T" last="Hallam">K T Hallam</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Victoria University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychology, Victoria University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Henry, L P" sort="Henry, L P" uniqKey="Henry L" first="L P" last="Henry">L P Henry</name><affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria</wicri:regionArea><wicri:noRegion>3052 Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Conus, P" sort="Conus, P" uniqKey="Conus P" first="P" last="Conus">P. Conus</name><affiliation wicri:level="4"><nlm:affiliation>Treatment and Early Intervention in Psychosis Program (TIPP), département de psychiatrie CHUV, université de Lausanne, clinique de Cery, Prilly, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Treatment and Early Intervention in Psychosis Program (TIPP), département de psychiatrie CHUV, université de Lausanne, clinique de Cery, Prilly</wicri:regionArea><orgName type="university">Université de Lausanne</orgName><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Ratheesh, A" sort="Ratheesh, A" uniqKey="Ratheesh A" first="A" last="Ratheesh">A. Ratheesh</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kader, L" sort="Kader, L" uniqKey="Kader L" first="L" last="Kader">L. Kader</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Wong, M Th" sort="Wong, M Th" uniqKey="Wong M" first="M Th" last="Wong">M Th Wong</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Mcgorry, P D" sort="Mcgorry, P D" uniqKey="Mcgorry P" first="P D" last="Mcgorry">P D Mcgorry</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M" last="Berk">M. Berk</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia; IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, 3220 Geelong, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, PO Box 281, Geelong, 3220 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia; IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, 3220 Geelong, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, PO Box 281, Geelong, 3220 Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26655594</idno><idno type="pmid">26655594</idno><idno type="doi">10.1016/j.eurpsy.2015.09.460</idno><idno type="wicri:Area/Main/Corpus">001A05</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001A05</idno><idno type="wicri:Area/Main/Curation">001A05</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001A05</idno><idno type="wicri:Area/Main/Exploration">001A05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study.</title><author><name sortKey="Daglas, R" sort="Daglas, R" uniqKey="Daglas R" first="R" last="Daglas">R. Daglas</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia. Electronic address: rose.daglas@orygen.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cotton, S M" sort="Cotton, S M" uniqKey="Cotton S" first="S M" last="Cotton">S M Cotton</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Allott, K" sort="Allott, K" uniqKey="Allott K" first="K" last="Allott">K. Allott</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Yucel, M" sort="Yucel, M" uniqKey="Yucel M" first="M" last="Yücel">M. Yücel</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Brain and Mental Health Laboratory (BMH), School of Psychological Sciences & Monash Biomedical Imaging Facility, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Brain and Mental Health Laboratory (BMH), School of Psychological Sciences & Monash Biomedical Imaging Facility, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Macneil, C A" sort="Macneil, C A" uniqKey="Macneil C" first="C A" last="Macneil">C A Macneil</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Hasty, M K" sort="Hasty, M K" uniqKey="Hasty M" first="M K" last="Hasty">M K Hasty</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Murphy, B" sort="Murphy, B" uniqKey="Murphy B" first="B" last="Murphy">B. Murphy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychiatry, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C" last="Pantelis">C. Pantelis</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Hallam, K T" sort="Hallam, K T" uniqKey="Hallam K" first="K T" last="Hallam">K T Hallam</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Victoria University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychology, Victoria University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Henry, L P" sort="Henry, L P" uniqKey="Henry L" first="L P" last="Henry">L P Henry</name><affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria</wicri:regionArea><wicri:noRegion>3052 Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Conus, P" sort="Conus, P" uniqKey="Conus P" first="P" last="Conus">P. Conus</name><affiliation wicri:level="4"><nlm:affiliation>Treatment and Early Intervention in Psychosis Program (TIPP), département de psychiatrie CHUV, université de Lausanne, clinique de Cery, Prilly, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Treatment and Early Intervention in Psychosis Program (TIPP), département de psychiatrie CHUV, université de Lausanne, clinique de Cery, Prilly</wicri:regionArea><orgName type="university">Université de Lausanne</orgName><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Ratheesh, A" sort="Ratheesh, A" uniqKey="Ratheesh A" first="A" last="Ratheesh">A. Ratheesh</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kader, L" sort="Kader, L" uniqKey="Kader L" first="L" last="Kader">L. Kader</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Wong, M Th" sort="Wong, M Th" uniqKey="Wong M" first="M Th" last="Wong">M Th Wong</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Mcgorry, P D" sort="Mcgorry, P D" uniqKey="Mcgorry P" first="P D" last="Mcgorry">P D Mcgorry</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M" last="Berk">M. Berk</name><affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia; IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, 3220 Geelong, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, PO Box 281, Geelong, 3220 Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia; IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, 3220 Geelong, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, PO Box 281, Geelong, 3220 Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">European psychiatry : the journal of the Association of European Psychiatrists</title><idno type="eISSN">1778-3585</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Antimanic Agents (therapeutic use)</term><term>Antipsychotic Agents (therapeutic use)</term><term>Bipolar Disorder (drug therapy)</term><term>Bipolar Disorder (psychology)</term><term>Cognition (drug effects)</term><term>Dibenzothiazepines (therapeutic use)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Humans (MeSH)</term><term>Intelligence (MeSH)</term><term>Lithium Compounds (therapeutic use)</term><term>Male (MeSH)</term><term>Memory (MeSH)</term><term>Quetiapine Fumarate (therapeutic use)</term><term>Single-Blind Method (MeSH)</term><term>Time Factors (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>Verbal Learning (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Antimaniacodépressifs (usage thérapeutique)</term><term>Apprentissage verbal (MeSH)</term><term>Cognition (effets des médicaments et des substances chimiques)</term><term>Composés du lithium (usage thérapeutique)</term><term>Dibenzothiazépines (usage thérapeutique)</term><term>Facteurs temps (MeSH)</term><term>Femelle (MeSH)</term><term>Fumarate de quétiapine (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Intelligence (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Mémoire (MeSH)</term><term>Méthode en simple aveugle (MeSH)</term><term>Neuroleptiques (usage thérapeutique)</term><term>Résultat thérapeutique (MeSH)</term><term>Trouble bipolaire (psychologie)</term><term>Trouble bipolaire (traitement médicamenteux)</term><term>Études de suivi (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimanic Agents</term><term>Antipsychotic Agents</term><term>Dibenzothiazepines</term><term>Lithium Compounds</term><term>Quetiapine Fumarate</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bipolar Disorder</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Trouble bipolaire</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Bipolar Disorder</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Trouble bipolaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antimaniacodépressifs</term><term>Composés du lithium</term><term>Dibenzothiazépines</term><term>Fumarate de quétiapine</term><term>Neuroleptiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Intelligence</term><term>Male</term><term>Memory</term><term>Single-Blind Method</term><term>Time Factors</term><term>Treatment Outcome</term><term>Verbal Learning</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Apprentissage verbal</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Intelligence</term><term>Jeune adulte</term><term>Mâle</term><term>Mémoire</term><term>Méthode en simple aveugle</term><term>Résultat thérapeutique</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and month 12 follow-up time-points.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>There was a significant interaction between group and time in phonemic fluency at the 3-month and 12-month endpoints, reflecting greater improvements in performance in lithium-treated participants relative to quetiapine-treated participants. After controlling for multiple comparisons, there were no other significant interactions between group and time for other measures of cognition.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Although the effects of lithium and quetiapine treatment were similar for most cognitive domains, the findings imply that early initiation of lithium treatment may benefit the trajectory of cognition, specifically verbal fluency in young people with bipolar disorder. Given that cognition is a major symptomatic domain of bipolar disorder and has substantive effects on general functioning, the ability to influence the trajectory of cognitive change is of considerable clinical importance.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">26655594</PMID><DateCompleted><Year>2016</Year><Month>08</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1778-3585</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>European psychiatry : the journal of the Association of European Psychiatrists</Title><ISOAbbreviation>Eur Psychiatry</ISOAbbreviation></Journal><ArticleTitle>A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study.</ArticleTitle><Pagination><MedlinePgn>20-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eurpsy.2015.09.460</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0924-9338(15)00641-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and month 12 follow-up time-points.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was a significant interaction between group and time in phonemic fluency at the 3-month and 12-month endpoints, reflecting greater improvements in performance in lithium-treated participants relative to quetiapine-treated participants. After controlling for multiple comparisons, there were no other significant interactions between group and time for other measures of cognition.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Although the effects of lithium and quetiapine treatment were similar for most cognitive domains, the findings imply that early initiation of lithium treatment may benefit the trajectory of cognition, specifically verbal fluency in young people with bipolar disorder. Given that cognition is a major symptomatic domain of bipolar disorder and has substantive effects on general functioning, the ability to influence the trajectory of cognitive change is of considerable clinical importance.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Daglas</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia. Electronic address: rose.daglas@orygen.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cotton</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allott</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yücel</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Brain and Mental Health Laboratory (BMH), School of Psychological Sciences & Monash Biomedical Imaging Facility, Monash University, Clayton, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macneil</LastName><ForeName>C A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasty</LastName><ForeName>M K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murphy</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Monash University, Clayton, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pantelis</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161, Barry Street, Carlton South, 3053 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hallam</LastName><ForeName>K T</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Department of Psychology, Victoria University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henry</LastName><ForeName>L P</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conus</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Treatment and Early Intervention in Psychosis Program (TIPP), département de psychiatrie CHUV, université de Lausanne, clinique de Cery, Prilly, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ratheesh</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kader</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>M Th</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGorry</LastName><ForeName>P D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Orygen Youth Health-Clinical Program, 35, Poplar Road, 3052 Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berk</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, Locked Bag 10 (35, Poplar Road), Parkville, 3052 Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052 Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, Australia; IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, 3220 Geelong, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, PO Box 281, Geelong, 3220 Victoria, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Psychiatry</MedlineTA><NlmUniqueID>9111820</NlmUniqueID><ISSNLinking>0924-9338</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018692">Antimanic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003987">Dibenzothiazepines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018020">Lithium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>2S3PL1B6UJ</RegistryNumber><NameOfSubstance UI="D000069348">Quetiapine Fumarate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018692" MajorTopicYN="N">Antimanic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001714" MajorTopicYN="N">Bipolar Disorder</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003987" MajorTopicYN="N">Dibenzothiazepines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007360" MajorTopicYN="N">Intelligence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018020" MajorTopicYN="N">Lithium Compounds</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069348" MajorTopicYN="N">Quetiapine Fumarate</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014706" MajorTopicYN="N">Verbal Learning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bipolar disorder</Keyword><Keyword MajorTopicYN="N">Cognition</Keyword><Keyword MajorTopicYN="N">Early intervention</Keyword><Keyword MajorTopicYN="N">Lithium</Keyword><Keyword MajorTopicYN="N">Mania</Keyword><Keyword MajorTopicYN="N">Quetiapine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26655594</ArticleId><ArticleId IdType="pii">S0924-9338(15)00641-0</ArticleId><ArticleId IdType="doi">10.1016/j.eurpsy.2015.09.460</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Suisse</li></country><region><li>Canton de Vaud</li><li>Victoria (État)</li></region><settlement><li>Lausanne</li><li>Melbourne</li></settlement><orgName><li>Université de Lausanne</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Daglas, R" sort="Daglas, R" uniqKey="Daglas R" first="R" last="Daglas">R. Daglas</name></region><name sortKey="Allott, K" sort="Allott, K" uniqKey="Allott K" first="K" last="Allott">K. Allott</name><name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M" last="Berk">M. Berk</name><name sortKey="Cotton, S M" sort="Cotton, S M" uniqKey="Cotton S" first="S M" last="Cotton">S M Cotton</name><name sortKey="Hallam, K T" sort="Hallam, K T" uniqKey="Hallam K" first="K T" last="Hallam">K T Hallam</name><name sortKey="Hasty, M K" sort="Hasty, M K" uniqKey="Hasty M" first="M K" last="Hasty">M K Hasty</name><name sortKey="Henry, L P" sort="Henry, L P" uniqKey="Henry L" first="L P" last="Henry">L P Henry</name><name sortKey="Kader, L" sort="Kader, L" uniqKey="Kader L" first="L" last="Kader">L. Kader</name><name sortKey="Macneil, C A" sort="Macneil, C A" uniqKey="Macneil C" first="C A" last="Macneil">C A Macneil</name><name sortKey="Mcgorry, P D" sort="Mcgorry, P D" uniqKey="Mcgorry P" first="P D" last="Mcgorry">P D Mcgorry</name><name sortKey="Murphy, B" sort="Murphy, B" uniqKey="Murphy B" first="B" last="Murphy">B. Murphy</name><name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C" last="Pantelis">C. Pantelis</name><name sortKey="Ratheesh, A" sort="Ratheesh, A" uniqKey="Ratheesh A" first="A" last="Ratheesh">A. Ratheesh</name><name sortKey="Wong, M Th" sort="Wong, M Th" uniqKey="Wong M" first="M Th" last="Wong">M Th Wong</name><name sortKey="Yucel, M" sort="Yucel, M" uniqKey="Yucel M" first="M" last="Yücel">M. Yücel</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Conus, P" sort="Conus, P" uniqKey="Conus P" first="P" last="Conus">P. 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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26655594" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |